• 大阪大学卒業、大阪大学大学院修士課程（薬学）修了、薬学博士（北海道大学）
  国立がんセンター研究所腫瘍遺伝子研究部研究員、同研究部室長、国立がんセンター研究所ＤＮＡメチル化とゲノム機能プロジェクト・プロジェクトリーダーを経て現職。

【researchmap】
https://researchmap.jp/read0160883

1. Shiraishi, M., Noguchi, M., Shimosato, Y. and Sekiya, T. (1989) Amplification of protooncogenes in surgical specimens of human lung carcinomas. Cancer Res.,49, 6474–6479.
2. Shiraishi, M., Lerman, L. S. and Sekiya, T. (1995) Preferential isolation of DNA fragments associated with CpG islands. Proc. Natl. Acad. Sci. USA,92, 4229–4233.
3. Shiraishi, M., Oates, A. J., Xu, L., Hosoda, F., Ohki, M., Alitalo, T., Lerman, L. S. and Sekiya, T. (1998) The isolation of CpG islands from human chromosomal regions 11q13 and Xp22 by segregation of partly melted molecules. Nucleic Acids Res.,26, 5544–5550.
4. Shiraishi, M., Chuu, Y. H. and Sekiya, T. (1999) Isolation of DNA fragments associated with methylated CpG islands in human adenocarcinomas of the lung using a methylated DNA binding column and denaturing gradient gel electrophoresis. Proc. Natl. Acad. Sci. USA,96, 2913–2918.
5. Shiraishi, M., Sekiguchi, A., Terry, M. J., Oates, A. J., Miyamoto, Y., Chuu, Y. H., Munakata, M. and Sekiya, T. (2002) A comprehensive catalog of CpG islands methylated in human lung adenocarcinomas for the identification of tumor suppressor genes. Oncogene, 21, 3804–3813.
6. Koizume, S., Tachibana, K., Sekiya, T., Hirohashi, S. and Shiraishi, M. (2002) Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells. Nucleic Acids Res., 30, 4770–4780.
7. Hayatsu, H., Negishi, K. and Shiraishi, M. (2004) DNA methylation analysis: Speedup of bisulfite-mediated deamination of cytosine in the genomic sequencing procedure. Proc. Jpn. Acad., 80(B), 189–194.
8. Tachibana, K., Takeda, K. and Shiraishi, M. (2004) 5-Aza-2’-deoxycytidine reactivates the CDH1 gene without influencing methylation of the entire CpG island or histone modification in a human cancer cell line. Proc. Jpn. Acad., 80(B), 342–348.
9. Shiraishi, M. and Hayatsu, H. (2004) High-speed conversion of cytosine to uracil in bisulfite genomic sequencing analysis of DNA methylation. DNA Res., 11, 409–415.
10. Ishimaru, N., Fukuchi, M., Hirai, A., Chiba, Y., Tamura, T., Takahashi, N., Tabuchi, A., Tsuda, M., and Shiraishi, M. (2010) Differential regulation of BDNF and NT-3 genes by trichostatin A and 5-aza-2’-deoxycytidine in Neuro-2a cells. Biochem. Biophys. Res. Commun. 394, 173–177.