• 【学位・学歴】
  千葉大学薬学部総合薬品科学科　卒業
  千葉大学大学院薬学研究科博士前期課程　修了、修士（薬学）千葉大学
  千葉大学大学院薬学研究科博士後期課程　中退、博士（薬学）千葉大学

• 【職歴】
  千葉大学薬学部 教務職員
  千葉大学大学院薬学研究院 助手
  千葉大学大学院薬学研究院 講師
  米国NIH/NIDCR Visiting Fellow
  千葉大学大学院薬学研究院 准教授 を経て現職

• 【資格】
  薬剤師

生物系薬学／生化学、分子生物学

ポリアミンと相互作用する生体分子の機能及び遺伝子発現制御機構の解析による創薬基盤研究

【researchmap】
https://researchmap.jp/read0055545

• 【主な論文／総説】
  ・Nishimura, K., Okamoto, M, Shibue, R., Mizuta, T., Shibayama, T., Yoshino, T., Murakami, T., Yamaguchi, M., Tanaka, S., Toida, T., Igarashi, K.: KLF4 is required for suppression of histamine synthesis by polyamines during bone marrow-derived mast cell differentiation. PLoS One. 15, e0229744 (2020)
  ・Ohta, R., Oguro, A., Nishimura, K., Murai, K., Fujioka, H., Arisawa, M.: Design and synthesis of N1, N8-diacetylspermidine analogues having a linker with desired functional groups. Org. Biomol. Chem. 17, 867-875 (2019)
  ・Williams, A., He, W., Cress, B.F., Liu, X., Alexandria, J., Yoshizawa, H., Nishimura, K., Toida, T., Koffas, M., Linhardt, R.J.: Cloning and Expression of Recombinant Chondroitinase ACII and Its Comparison to the Arthrobacter aurescens Enzyme. Biotechnol. J. 12, 201700239 (2017)
  ・Imamura, M., Higashi, K., Yamaguchi, K., Asakura, K., Furihata, T., Terui, Y., Satake, T., Maegawa, J., Yasumura, K., Ibuki, A., Akase, T., Nishimura, K., Kashiwagi, K., Linhardt, R.J., Igarashi, K., Toida, T.: Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2. Sci. Rep. 6, 33549 (2016)
  ・西村和洋: eIF5Aとハイプシンの今昔物語．ポリアミン 3, 2-7 (2016)
  ・Suabjakyong, P., Nishimura, K., Toida, T., Van Griensven, L. J.: Structural characterization and immunomodulatory effects of polysaccharides from Phellinus linteus and Phellinus igniarius on the IL-6/IL-10 cytokine balance of the mouse macrophage cell lines (RAW 264.7). Food Funct. 6, 2834-2844 (2015)
  ・Weisel, F.C., Kloepping, C., Pichl, A., Sydykov, A., Kojonazarov, B., Wilhelm, J., Roth, M., Ridge, K.M., Igarashi, K., Nishimura, K., Maison, W., Wackendorff, C., Klepetko, W., Schermuly, R.T., Ghofrani, H.A., Grimminger, F., Seeger, W., Weissmann, N., Kwapiszewska, G.: Impact of S-adenosylmethionine decarboxylase 1 in pulmonary vascular remodeling. Circulation 129, 1510-1523 (2014)
  ・Saiki, R., Hayashi, D., Ikuo, Y., Nishimura, K., Ishii, I., Kobayashi, K., Chiba, K., Toida, T., Kashiwagi, K., Igarashi, K.: Acrolein stimulation of the synthesis of IL-6 and CRP in thrombosis model mice and cultured cells. J. Neurochem. 127, 652-659 (2013)
  ・Yamashita, T., Nishimura, K., Saiki, R., Okudaira, H., Tome, M., Higashi, K., Nakamura, M., Terui, Y., Fujiwara, K., Kashiwagi, K., Igarashi, K.: Role of polyamines at the G1/S boundary and G2/M phase of the cell cycle. Int. J. Biochem. Cell Biol. 45, 1042-1050 (2013)
  ・Nishimura, K., Lee, S. B., Park, J. H., Park, M. H.: Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development. Amino Acids 42, 703-710 (2012)
  ・Saiki, R., Nishimura, K., Ishii, I., Omura, T., Okuyama, S., Kashiwagi, K., Igarashi, K.: Intense correlation between brain infarction and protein-conjugated acrolein. Stroke 40, 3356-3361 (2009)
  ・Nishimura, K., Okudaira, H., Ochiai, E., Higashi, K., Kaneko, M., Ishii, I., Nishimura, T., Dohmae, N., Kashiwagi, K., Igarashi, K.: Identification of proteins whose synthesis is preferentially enhanced by polyamines at the level of translation in mammalian cells. Int. J. Biochem. Cell Biol. 41, 2251-2261 (2009)
  ・Higashi, K., Terui, Y., Suganami, A., Tamura, Y., Nishimura, K., Kashiwagi, K., Igarashi, K.: Selective structural change by spermidine of bulged-out region of double-stranded RNA and its effect on RNA function. J. Biol. Chem. 283, 32989-32994 (2008)
  ・Nishimura, K., Sakuma, A., Yamashita, T., Hirokawa, G., Kashiwagi, K., Imataka, H., Igarashi, K.: Minor contribution of an internal ribosome entry site in the 5’-UTR of ornithine decarboxylase mRNA on its translation. Biochem. Biophys. Res. Commun. 364, 124-130 (2007)
  ・Nishimura, K., Shiina, R., Kashiwagi, K., Igarashi, K.: Decrease in polyamines with aging and their ingestion from food and drink. J. Biochem. 139, 81-90 (2006)
  ・Nishimura, K., Murozumi, K., Shirahata, A., Park, M. H., Kashiwagi, K., and Igarashi, K.: Independent roles of eIF5A and polyamines in cell proliferation. Biochem. J. 385, 779-785 (2005)
  ・Nishimura, K., Nakatsu, F., Kashiwagi, K., Ohno, H., Saito, T., Igarashi, K.: Essential role of S-adenosylmethionine decarboxylase in mouse embryonic development. Genes Cells 7, 41-47 (2002)
  
  【科研費】
  ・基盤研究（C）（一般）「ポリアミンによるプリンヌクレオチド合成経路促進機構の解明」（令和2～4年度）

【E-mail】kaznishi＠iuhw.ac.jp [＠は半角に変更]