【学歴】
宇都宮大学農学部卒業 農学士
宇都宮大学大学院修士課程修了 農学修士
静岡県立大学大学院博士後期課程 博士（環境科学）

日本毒性学会評議員、安全性評価研究会幹事

【職歴】
日本たばこ産業株式会社 医薬総合研究所安全性研究所 研究員、研究企画室長、副所長

【資格】
日本毒性学会認定トキシコロジスト、高等学校教諭（理科）

医薬品安全性学、毒性学、栄養化学

化学物質の安全性評価手法の確立

【researchmap】
https://researchmap.jp/kobayashi-akio

【主な原著論文】

1. Impact of microsampling on toxicological evaluation in rodent safety studies. Kazuaki Takahashi, Norimichi Hattori, Hideaki Yokoyama, Fumihiro Jinno, Hirohiko Ohtsuka, Keiko Nakai, Asuka Takumi, Yusuke Shibui, Koki Yamaguchi, Taishi Shimazaki, Yoichi Tanaka, Kosuke Saito, Akio Kobayashi, Yoshiro Saito, Journal of applied toxicology , (2023)
2. Active-phase Plasma Alkaline Phosphatase Isozyme Activity Is a Sensitive Biomarker for Excessive Fructose Intake. Yusuke Suzuki, Daigo Yokoyama, Chizuru Matsuura, Kazuma Kondo, Taishi Shimazaki, Katsunori Ryoke, Akio Kobayashi, Hiroyuki Sakakibara In vivo (Athens, Greece) 37(5) 1967-1974 (2023)
3. Novel Biomarker Establishment for Evaluation of Excessive Fructose Consumption Using a Rat Model. Yusuke Suzuki, Kazuma Kondo, Kaoru Toyoda, Yuki Tanaka, Akio Kobayashi, Daigo Yokoyama, Hiroyuki Sakakibara In vivo (Athens, Greece) 37(1) 173-181 (2023)
4. Phosphatidylcholine (18:0/20:4), a potential biomarker to predict ethionamide-induced hepatic steatosis in rats. Kyotaka Muta, Kosuke Saito, Yusuke Kemmochi, Taku Masuyama, Akio Kobayashi, Yoshiro Saito, Shoichiro Sugai Journal of applied toxicology : JAT 42(9) 1533-1547 (2022)
5. Enhancement of acetaminophen-induced chronic hepatotoxicity in spontaneously diabetic torii (SDT) rats. Kazuma Kondo, Naohito Yamada, Yusuke Suzuki, Tatsuji Hashimoto, Kaoru Toyoda, Tadakazu Takahashi, Akio Kobayashi, Shoichiro Sugai, Kouichi Yoshinari The Journal of toxicological sciences 45(5) 245-260 (2020)
6. Specificity of transaminase activities in the prediction of drug-induced hepatotoxicity. Akio Kobayashi, Yusuke Suzuki, Shoichiro Sugai The Journal of toxicological sciences 45(9) 515-537 (2020)
7. Kobayashi A., Yokoyama H., Kataoka J., Ishida T., Kuno H., Sugai S., Sakakibara H. and Shimoi K.: Effects of spaced feeding on gene expression of hepatic transaminase and gluconeogenic enzymes in rats. J. Toxicol. Sci., 36(3), 325-337, (2011).
8. Kobayashi A., Oshida S., Yamazaki Y., Maekawa T., Kuno H., Sugai S., Sakakibara H. and Shimoi K.: Relationships between plasma and tissue transaminase activities in rats maintained under different feeding conditions. J. Toxicol. Sci, 35(5), 639-652, (2010).
9. Kobayashi A., Suzuki Y., Kuno H., Sugai S., Sakakibara H. and Shimoi K.: Effects of fenofibrate on plasma and hepatic transaminase activities and hepatic transaminase gene expression in rats. J. Toxicol. Sci., 34(4), 377-397, (2009).
10. Kobayashi A., Takahashi T, Sugai S., Miyakawa Y, Iwatsuka H and Yamaguchi T: Urinary excretion of oxidative metabolites of bilirubin in fenofibrate treated rats. J.Toxicol. Sci., 28(2), 71-75, (2003).

【E-mail】kobayashi-akio＠iuhw.ac.jp [＠は半角に変更]