【学歴】
宇都宮大学農学部卒業 農学士
宇都宮大学大学院修士課程修了 農学修士
静岡県立大学大学院博士後期課程 博士（環境科学）

日本毒性学会理事・評議員、安全性評価研究会幹事

【職歴】
日本たばこ産業株式会社 医薬総合研究所安全性研究所 研究員、研究企画室長、副所長

【資格】
日本毒性学会認定トキシコロジスト、高等学校教諭（理科）

医薬品安全性学、毒性学、栄養化学

化学物質の安全性評価手法の確立

【researchmap】
https://researchmap.jp/kobayashi-akio

【主な原著論文】

1. Phosphatidylcholine (18:0/20:4), a potential biomarker to predict ethionamide-induced hepatic steatosis in rats. Kyotaka Muta, Kosuke Saito, Yusuke Kemmochi, Taku Masuyama, Akio Kobayashi, Yoshiro Saito, Shoichiro Sugai, Journal of applied toxicology, in press
2. Kazuma Kondo, Naohito Yamada, Yusuke Suzuki, Tatsuji Hashimoto, Kaoru Toyoda, Tadakazu Takahashi, Akio Kobayashi, Shoichiro Sugai, Kouichi Yoshinari: Enhancement of acetaminophen-induced chronic hepatotoxicity in spontaneously diabetic torii (SDT) rats. , J. Toxicol. Sci., 45(5), 245-260, (2020)
3. Hideaki Yokoyama, Norimichi Hattori, Hirohiko Ohtsuka, Eiji Murata, Akio Kobayashi, Kyotaka Muta, Asuka Takumi, Harumi Kitaura, Fumihiro Jinno, Atsushi Iwai, Keiko Nakai, Kanae Mori, Kosuke Saito, Yoshiro Saito: Lack of toxicological influences by microsampling (50 µL) from jugular vein of rats in a collaborative 28-day study., J. Toxicol. Sci., 45(6), 319-325, (2020)
4. Goda K., Kobayashi A., Takahashi A., Takahashi T., Saito K., Maekawa K. and Saito Y.: Evaluation of the Potential Risk of Drugs to Induce Hepatotoxicity in Human-Relationships between Hepatic Steatosis Observed in Non-Clinical Toxicity Study and Hepatotoxicity in Humans. Int J. Mol. Sci., 18(4), 810, (2017).
5. Hiroyuki Sakakibara, Atsumi Suzuki, Akio Kobayashi, Keiko Motoyama, Asako Matsui, Kazutoshi Sayama, Ayako Kato, Norio Ohashi, Masanobu Akimoto, Tsutomu Nakayama and Kayoko Shimoi.: Social isolation stress induces hepatic hypertrophy in C57BL/6J mice. J. Toxicol. Sci., 37(5),1071-1076, (2012).
6. Kobayashi A., Yokoyama H., Kataoka J., Ishida T., Kuno H., Sugai S., Sakakibara H. and Shimoi K.: Effects of spaced feeding on gene expression of hepatic transaminase and gluconeogenic enzymes in rats. J. Toxicol. Sci., 36(3), 325-337, (2011).
7. Kobayashi A., Oshida S., Yamazaki Y., Maekawa T., Kuno H., Sugai S., Sakakibara H. and Shimoi K.: Relationships between plasma and tissue transaminase activities in rats maintained under different feeding conditions. J. Toxicol. Sci, 35(5), 639-652, (2010).
8. Kobayashi A., Suzuki Y., Kuno H., Sugai S., Sakakibara H. and Shimoi K.: Effects of fenofibrate on plasma and hepatic transaminase activities and hepatic transaminase gene expression in rats. J. Toxicol. Sci., 34(4), 377-397, (2009).
9. Kobayashi A., Takahashi T, Sugai S., Miyakawa Y, Iwatsuka H and Yamaguchi T: Urinary excretion of oxidative metabolites of bilirubin in fenofibrate treated rats. J.Toxicol. Sci., 28(2), 71-75, (2003).

【E-mail】kobayashi-akio＠iuhw.ac.jp [＠は半角に変更]