【学位・学歴】
東京薬科大学薬学部薬学科卒業　学士（薬学）
東京薬科大学大学院生命科学研究科生命科学専攻修了　修士（生命科学）
東京薬科大学大学院生命科学研究科生命科学専攻修了　博士（生命科学）

【職歴】
千葉大学大学院薬学研究院博士研究員、千葉科学大学薬学部薬学科教授を経て現職

【資格】
薬剤師、第１種作業環境測定士

生化学、分子生物学

生理活性物質ポリアミンの生理機能解明と医療への応用

【researchmap】
https://researchmap.jp/cjkks880

【著書】

1. Kashiwagi K., Terui Y., Igarashi K., Modulation of protein synthesis by polyamines in mammalian cells., Polyamines-Methods and Protocols (Humana Press) Methods in Molecular Biology, 1694, 325-336 (2017)
2. Igarashi K., Terui Y., Kashiwagi K., The polyamine modulon: genes encoding p roteins whose synthesis is enhanced by polyamines at the level of translation., Polyamines, a universal molecular nexus for growth, survival and specialised metabolism., Eds. Kusano T., and Suzuki H. (Springer Japan) 131-141 (2015)
3. Oshima T., Moriya T., Terui Y., Identification, Chemical synthesis, and Biological functions of unusual polyamines produced by extreme thermophiles., Polyamines-Methods and Protocols (Humana Press) Methods in Molecular Biology, 720, 81-111 (2011)

【論文】

1. Kobayashi T., Sakamoto A., Hisano T., Kashiwagi K., Igarashi K., Takao K., Uemura T., Furuchi T., Sugita Y., Moriya T., Oshima T., Terui Y., Caldomycin, a new guanidopolyamine produced by a novel agmatine homocoupling enzyme involved in homospermidine biosynthesis., Sci. Rep., 14(1), 7566 (2024)
2. Yoshida M., Uemura T., Mizoi M., Waragai M., Sakamoto A., Terui Y., Kashiwagi K., Igarashi K., Urinary amino acid-conjugated acrolein and taurine as new biomarkers for detection of dementia., J. Alzheimer’s Dis., 92, 361-369 (2023)
3. Uemura T., Uchida M., Nakamura M., Shimekake M., Sakamoto A., Terui Y., Higashi K., Ishii I., Kashiwagi K., Igarashi K., A search for acrolein scavengers among food components., Amino Acids, 55, 509-518 (2023)
4. Kobayashi T., Sakamoto A., Kashiwagi K., Igarashi K., Takao K., Uemura T., Moriya T., Oshima T., Terui Y., Putrescine biosynthesis from agmatine by arginase (TtARG) in Thermus thermophilus., J. Biochem., 174, 81-88 (2023)
5. Sakamoto A., Terui Y., Igarashi K., Kashiwagi K. Transient receptor potential ankyrin 1 (TRPA1) channel mediates acrolein cytotoxicity in human lung cancer cells., Int. J. Mol. Sci., 24, 11847 (2023)
6. Sakamoto A., Tamakoshi M., Moriya T., Oshima T., Takao K., Sugita Y., Furuchi T., Niitsu M., Uemura T., Igarashi K., Kashiwagi K. Terui Y., Polyamines produced by an extreme thermophile are essential for cell growth at high temperature., J. Biochem., 172, 109-115 (2022)
7. Sakamoto A., Terui Y., Uemura T., Igarashi K., Kashiwagi K., Translational Regulation of Clock Genes BMAL1 and REV-ERBα by Polyamines., Int. J. Mol. Sci., 22, 1307 (2021)
8. Ito D., Ge D., Kogure N., Manaka H., Terui Y., Takayama H., Linhardt RJ., Toida T., Higashi K., Poly-ion complex (PIC) formation of heparin and polyamines: PIC with tetrakis(3-aminopropyl)ammonium allows sustained release of heparin., Heliyon, 6, e05168 (2020)
9. Uemura T., Suzuki T., Ko K., Nakamura M., Dohmae N., Sakamoto A., Terui Y., Toida T., Kashiwagi K., Igarashi K., Structural change and degradation of cytoskeleton due to the acrolein conjugation with vimentin and actin during brain infarction., Cytoskeleton (Hoboken), 77, 414-421 (2020)
10. Sakamoto, A., Terui, Y., Uemura, T., Igarashi, K., Kashiwagi, K., Polyamines regulate gene expression by stimulating translation of histone acetyltransferase mRNAs., J. Biol. Chem., 95, 8736-8745 (2020)
11. Sakamoto, A., Uemura, T., Terui, Y., Yoshida, M., Fukuda, K., Nakamura, T., Kashiwagi, K., Igarashi, K., Development of an ELISA for measurement of urinary 3-hydroxypropyl mercapturic acid (3-HPMA), the marker of stroke., Med. Sci., 8(3), 33. (2020)
12. Sakamoto A., Sahara J., Kawai G., Yamamoto K., Ishihama A., Uemura T., Igarashi K., Kashiwagi K., Terui Y., Polyamines functions through translational repression of specific proteins encoded by polyamine modulon., Int. J. Mol. Sci., 21, 2406 (2020)
13. Uemura T., Suzuki T., Ko K., Watanabe K., Dohmae N., Sakamoto A., Terui Y., Toida T., Kashiwagi K., Igarashi K., Inhibition of dendritic spine extension through acrolein conjugation with α-, β-tubulin proteins., Int. J. Biochem. Cell. Biol., 113. 58-66. (2019)

【特許】

1. 発明の名称：RNA追跡方法
   発明者：大島泰郎、照井祐介、河合剛太、猪股恵美礼、野村祐介、原田和雄
   出願人：大陽日酸株式会社
   特許番号：第4733936号
   
2. 発明の名称：RNA安定化剤ならびにこのRNA安定化剤を用いたRNA安定化方法および複合体安定化方法
   発明者：大島泰郎、照井祐介、河合剛太、猪股恵美礼、野村祐介、原田和雄
   出願人：大陽日酸株式会社
   公開番号：2006-020575
   

【E-mail】yterui＠iuhw.ac.jp [＠は半角に変更]