【学歴・学位】
東北大学薬学部卒業
東北大学大学院薬学研究科 修士（薬学）
東北大学大学院薬学研究科 博士（薬学）

【職歴】
米国ミズーリ大学研究講師、東北大学薬学部助手、講師、准教授を経て現職

神経変性疾患の発症における細胞膜の役割
銅の細胞内取り込みの分子メカニズム

【researchmap】
https://researchmap.jp/TMiura

【主な原著論文】

1. " “Potential role of serotonin as a biological reductant associated with copper transportation”
   Kaede Saito, Kasumi Watanabe, Risa Yanaoka, Lisa Kageyama, Takashi Miura
   J. Inorg. Biochem. 199, 110770 (2019).
2. " “Examination of the association states of dehydroergosterol towards understanding the association structures of sterols in a membrane”
   Kunisato Kuroi, Masatomo Imaizumi, Takashi Miura, Takakazu Nakabayashi
   Biochem. Biophys. Res. Comm. 515, 228-233 (2019).
3. " “Comparison of extracellular Cys/Trp motif between Schizosaccharomyces pombe Ctr4 and Ctr5”
   Mariko Okada, Takashi Miura, Takakazu Nakabayashi
   J. Inorg. Biochem. 169, 97-105 (2017).
4. " “Acquisition of pro-oxidant activity of fALS-linked SOD1 mutants as revealed using circular dichroism and UV-resonance Raman spectroscopy”
   Nobuhiro Fujimaki, Ken Nishiya, Takashi Miura, Takakazu Nakabayashi
   Chem. Phys. 479, 5-10 (2016).
5. "Copper(I) stabilization by cysteine/tryptophan motif in the extracellular domain of Ctr4" Mariko Okada and Takashi Miura, J. Inorg. Biochem. 159, 45-49 (2016).
6. "Disperse Orange 3 as a resonance Raman probe for measuring membrane order" Yuki Numakura and Takashi Miura, FEBS Open Bio, 5, 859-863 (2015).
7. "Effect of amyloid β-peptide on the fluidity of phosphatidylcholine membranes: Uses and limitations of diphenylhexatriene fluorescence anisotropy" Masako Suzuki and Takashi Miura, Biochim. Biophys. Acta, 1848, 753-759 (2015).
8. "His-Trp Cation-π Interaction and Its Structural Role in an α-Helical Dimer of HIV-1 Vpr Protein" Takayuki Kamiyama, Takashi Miura, and Hideo Takeuchi, Biophys. Chem., 173-174, 8-14 (2013).
9. "Evidence for the Cation-π Interaction between Cu2+ and Tryptophan" Hanami Yorita, Kohei Otomo, Hirotsugu Hiramatsu, Akira Toyama, Takashi Miura, and Hideo Takeuchi, J. Am. Chem. Soc., 130, 15266-15267 (2008).
10. "Non-Electrostatic Binding and Self-Association of Amyloid β-Peptide on the Surface of Tightly Packed Phosphatidylcholine Membranes" Mayumi Yoda, Takashi Miura, and Hideo Takeuchi, Biochem. Biophys. Res. Commun., 376, 56-59 (2008).
11. "Clustered Negative Charges on the Lipid Membrane Surface Induce β-Sheet Formation of Prion Protein Fragment 106-126" Takashi Miura, Mayumi Yoda, Naoyuki Takaku, Takanori Hirose, and Hideo Takeuchi. Biochemistry, 46, 11589-11597 (2007).
12. "Copper Reduction by the Octapeptide Repeat Region of Prion Protein: pH Dependence and Implications in Cellular Copper Uptake" Takashi Miura, Satoshi Sasaki, Akira Toyama, and Hideo Takeuchi, Biochemistry, 44, 8712-8720 (2005).
13. "Copper selectively triggers β-sheet assembly of an N-terminally truncated amyloid β-peptide beginning with Glu3" T. Miura, S. Mitani, C. Takanashi & N. Mochizuki, J. Inorg. Biochem. 98, 10-14 (2004).
14. "Protonation of histidine and histidine-tryptophan interaction in the activation of the M2 ion channel from influenza A virus" A. Okada, T. Miura & H. Takeuchi, Biochemistry 40, 6053-6060 (2001).
15. "Metal binding modes of Alzheimer's amyloid β-peptide in insoluble aggregates and soluble complexes" T. Miura, K. Suzuki, N. Kohata & H. Takeuchi, Biochemistry 39, 7024-7031 (2000).

【主な総説、著書】

1. "脂質膜と金属イオンによるアミロイドβペプチドのコンホメーション制御" 三浦隆史、依田真由美、堤千裕、村山紀代子、竹内英夫、薬学雑誌 130, 495-501 (2010).
2. "Optical and vibrational spectroscopic methods" T. Miura & G. J. Thomas, Jr. Introduction to Biophysical Methods for Protein and Nucleic Acid Research (J. A. Glasel and M. P. Deutscher, Eds.) Academic Press, 261-315 (1995).
3. "Raman spectroscopy of proteins and their assemblies" T. Miura & G. J. Thomas, Jr. Subcellular Biochemistry 24, 55-99 (1995).