【学歴】
星薬科大学薬学部衛生薬学科卒業
博士（薬学）星薬科大学
博士（医学）東京医科大学

【職歴】
株式会社実生研筑波研究所研究員、東京医科大学医学部助手、国際医療福祉大学講師・准教授を経て現職

【資格】
薬剤師

神経精神薬理学

ストレス性精神疾患の病態解明と新規治療戦略の開発

【researchmap】
https://researchmap.jp/read0052123

1. Takahashi K, Tsuji M, Nakagawasai O, Miyagawa K, Kurokawa K, Mochida-Saito A, Iwasa M, Iwasa H, Suzuki S, Takeda H, Tadano T. Anxiolytic effects of Enterococcus faecalis 2001 on a mouse model of colitis. Sci Rep 14, 11519, 2024. (Original article)
2. Takahashi K, Tsuji M, Nakagawasai O, Katsuyama S, Miyagawa K, Kurokawa K, Mochida-Saito A, Takeda H, Tadano T. Polarization to M1-type microglia in the hippocampus is involved in depression-like behavior in a mouse model of olfactory dysfunction. Neurochem Int 175, 105723, 2024. (Original article)
3. Takahashi K, Kurokawa K, Miyagawa K, Mochida-Saito A, Takeda H, Tsuji M. Repeated antibiotic drug treatment negatively affects memory function and glutamatergic nervous system of the hippocampus in mice. Neurosci Lett 825, 1377112024, 2024. (Original article)
4. Takahashi K, Kurokawa K, Hong L, Miyagawa K, Mochida-Saito A, Takeda H, Tsuji M. Hippocampal and gut AMPK activation attenuates enterocolitis-like symptoms and co-occurring depressive-like behavior in ulcerative colitis model mice: Involvement of brain-gut autophagy. Exp Neurol 373, 114671, 2024. (Original article)
5. Miyagishi H, Joyama A, Nango H, Nagayama K, Tsuji M, Takeda H, Kosuge Y. Cytoprotective effects of Hangekobokuto against corticosterone-induced cell death in HT22 cells. J Nat Med 78, 255-265, 2024. (Original article)
6. Arai I, Tsuji M, Saito S, Takeda H. Experimental study: Interleukin-31 augments morphine-induced antinociceptive activity and suppress tolerance development in mice. Int J Mol Sci 24, 16548, 2023.
7. Nomura A, Kurokawa K, Takahashi K, Miyagawa K, Mochida-Saito A, Takeda H, Tsuji M. Possible involvement of inflammasomes on the post-stroke cognitive impairment in a mouse model of embolic cerebral infarct. Physiol Behav 271, 114348, 2023.
8. Takahashi K, Hong L, Kurokawa K, Miyagawa K, Mochida-Saito A, Takeda H, Tsuji M. Brexpiprazole prevents colitis-induced depressive-like behavior through myelination in the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry 121, 110666, 2023. (Original article)
9. Takahashi K, Tsuji M, Nakagawasai O, Katsuyama S, Hong L, Miyagawa K, Kurokawa K, Mochida-Saito A, Takeda H, Tadano T. Donepezil prevents olfactory dysfunction and α-synuclein aggregation in the olfactory bulb by enhancing autophagy in zinc sulfate-treated mice. Behav Brain Res 438, 114175, 2023. (Original article)
10. Arai I, Tsuji M, Takahashi K, Saito S, Takeda H. Analyzing the antinociceptive effect of interleukin-31 in mice. Int J Mol Sci 24, 11563, 2023. (Original article)
11. Takahashi K, Kurokawa K, Hong L, Miyagawa K, Mochida-Saito A, Takeda H, Tsuji M. Correlation between the reduction in hippocampal SirT2 expression and depressive-like behaviors and neurological abnormalities in olfactory bulbectomized mice. Neurosci Res 182, 76-80, 2022. (Original article)
12. Miyagishi H, Tsuji M, Miyagawa K, Kurokawa K, Mochida-Saito A, Takahashi K, Kosuge Y, Ishige K, Takeda H. Possible role of transcriptional regulation of 5-HT1A receptor in the midbrain on unadaptation to stress in mice. Brain Res 1783, 147859, 2022. (Original article)
13. Takahashi K, Kurokawa K, Hong L, Miyagawa K, Mochida-Saito A, Iwasa M, Iwasa H, Nakagawasai O, Tadano T, Takeda H, Tsuji M. Antidepressant effects of Enterococcus faecalis 2001 through the regulation of prefrontal cortical myelination via the enhancement of CREB/BDNF and NF-κB p65/LIF/STAT3 pathways in olfactory bulbectomized mice. J Psychiatr Res 148, 137-148, 2022. (Original article)
14. Kimijima H, Miyagawa K, Kurokawa K, Mochida-Saito A, Takahashi K, Takeda H, Tsuji M. Trichostatin A, a histone deacetylase inhibitor, alleviates the emotional abnormality induced by maladaptation to stress in mice. Neurosci Lett 766, 136340, 2022. (Original article)
15. Arai I, Tsuji M, Takeda H, Akiyama N, Saito S. Capsaicin suppresses interleukin-31-induced itching partially involved in inhibiting the expression of dorsal root ganglion interleukin-31 receptor A in male mice. Neurobiol Pain 11, 100088, 2022. (Original article)
16. Kurokawa K, Takahashi K, Miyagawa K, Mochida-Saito A, Takeda H, Tsuji M. Activation of 5-HT1A receptor reduces abnormal emotionality in stress-maladaptive mice by alleviating decreased myelin protein in the ventral hippocampus. Neurochem Int 151, 105213, 2021. (Original article)
17. Akai H, Miyagawa K, Takahashi K, Mochida-Saito A, Kurokawa K, Takeda H, Tsuji M, Sugawara H, Yasaka K, Kunimatsu A, Inoue Y, Abe O, Ohtomo K, Kiryu S. Effects of gadolinium deposition in the brain on motor or behavioral function: a mouse model. Radiology 301, 409-416, 2021. (Original article)
18. Takahashi K, Kurokawa K, Hong L, Miyagawa K, Mochida-Saito A, Takeda H, Tsuji M. Disturbance of prefrontal cortical myelination in olfactory bulbectomized mice is associated with depressive-like behavior. Neurochem Int 148, 105112, 2021. (Original article)
19. Takahashi K, Tsuji M, Nakagawasai O, Katsuyama S, Miyagawa K, Kurokawa K, Mochida-Saito A, Iwasa M, Iwasa H, Takeda H, Tadano T. Activation of cholinergic system partially rescues olfactory dysfunction-induced learning and memory deficit in mice. Behav Brain Res 408, 113283, 2021. (Original article)
20. Takahashi K, Nakagawasai O, Nakajima T, Okubo M, Nishimura Y, Sakuma W, Yamagata R, Nemoto W, Miyagawa K, Kurokawa K, Mochida-Saito A, Tsuji M, Takeda H, Tadano T, Tan-No K. Dopamine D2 receptor supersensitivity in the hypothalamus of olfactory bulbectomized mice. Brain Res 1746, 147015, 2020. (Original article)
21. Kurokawa K,Tsuji M, Takahashi K, Miyagawa K, Mochida-Saito A, Takeda H. Leukemia inhibitory factor participates in the formation of stress adaptation via hippocampal myelination in mice. Neuroscience 446, 1-13, 2020. (Original article)
22. Takahashi K, Kurokawa K, Miyagawa K, Mochida-Saito A, Nemoto Y, Iwasa H, Nakagawasai O, Tadano T, Takeda H, Tsuji M. Antidementia effects of Enterococcus faecalis 2001 are associated with enhancement of hippocampal neurogenesis via the ERK-CREB-BDNF pathway in olfactory bulbectomized mice. Physiol Behav 223, 112997, 2020. (Original article)
23. Miyagishi H, Tsuji M, Miyagawa K, Kurokawa K, Mochida-Saito A, Takahashi K, Ishige K, Takeda H. Characterization of 5-HT1A receptor and transport protein KIF13A expression in the hippocampus of stress-adaptive and -maladaptive mice. Neuroscience let 733, 135082, 2020. (Original article)
24. Nagakura Y, Miwa M, Yoshida M, Miura R, Tanei S, Tsuji M, Takeda H. Spontaneous pain-associated facial expression and efficacy of clinically used drugs in the reserpine-induced rat model of fibromyalgia. Eur J Pharmacol 864, 172716, 2019. (Original article)
25. Tsuji M, Arai I, Miyagawa K, Miyagishi H, Saito A, Takeda K, Takeda H, Akiyama N, Saito S. Involvement of interleukin-31 receptor A in morphine-induced itching and antinociception in mice. Eur J Pain 23, 378-388, 2019. (Original article)
26. Miyagawa K, Tsuji M, Takeda H. Role of epigenetic mechanisms in the post-traumatic stress disorder and stress resistance. In: Pinna G, Izumi T (eds) Facilitating resilience after PTSD: a translational approach. NOVA Science Publishers, pp157-176, 2018 (Book)
27. Takeda K, Tsuji M, Miyagawa K, Takeda H. Involvement of brain 5-HT7 receptors in the formation of stress adaptation in mice. J Exp Res Pharmacol 2, 21-30, 2017. (Original article)
28. Ohno R, Miyagishi H, Tsuji M, Saito A, Miyagawa K, Kurokawa K, Takeda H. Yokukansan, a traditional Japanese herbal medicine,　enhances the anxiolytic effect of fluvoxamine and reduces cortical 5-HT2A receptor expression in mice. J Ethnopharmacol 216, 89-96, 2018. (Original article)
29. Saito A, Miyagawa K, Miyagishi H, Kurokawa K, Umeda A, Okada Y, Tsuji M, Takeda H. Possible involvement of monoamine neurons in the emotional abnormality in Kir6.2-deficient mice. Physiol Behav 188, 251-261, 2018. (Original article)
30. Miyagishi H, Tsuji M, Saito A, Miyagawa K, Takeda H. Inhibitory effect of yokukansan on the decrease in the hippocampal excitatory amino acid transporter EAAT2 in stress-maladaptive mice. J Tradit Complement Med 7, 371-374, 2017. (Original article)
31. Takeda K, Tsuji M, Miyagawa K, Takeda H. 5-HT7 receptor-mediated fear conditioning and possible involvement of extracellular signal-regulated kinase. Neurosci Lett 638, 69-75, 2017. (Original article)
32. Kato H, Tsuji M, Miyagawa K, Takeda Kotaro, Takeda H. Ethanol withdrawal-induced impaired recognition is reversed by chronic exposure to stress and the acute administration of corticosterone in mice. Biol Pharm Bull 39, 1631-1637, 2016. (Original article)
33. Nakatani Y, Amano T, Yamamoto H, Sakai N, Tsuji M, Takeda H. Yokukansan enhances the proliferation of B65 neuroblastoma. J Tradit Complement Med 6, 1-11, 2016. (Original article)
34. Arai I, Tsuji M, Miyagawa K, Takeda H, Akiyama N, Saito S. Repeated administration of IL-31 upregulates IL-31 receptor A (IL-31RA) in dorsal root ganglia and causes severe itch-associated scratching behaveour in mice. Exp Dermatol 24, 75-78, 2015. (Original article)
35. Miyagawa K, Tsuji M, Ishii D, Takeda K, Takeda H. Prenatal stress induces vulnerability to stress together with the disruption of central serotonin neurons in mice. Behav Brain Res 277, 1458-1465, 2015. (Original article)
36. Tsuji M, Miyagawa K, Takeda H. Epigenetic regulation of resistance to emotional stress: possible involvement of 5-HT1A receptor-mediated histone acetylation. J Pharmacol Sci 125, 347-354, 2014. (Review)
37. Tsuji M, Takeuchi T, Miyagawa K, Ishii D, Imai T, Takeda K, Kitajima M, Takeda H. Yokukansan, a traditional Japanese herbal medicine, alleviates the emotional abnormality induced by maladaptation to stress in mice. Phytomedicine 21, 363-371, 2014. (Original article)
38. Nakatani Y, Tsuji M, Amano T, Miyagawa K, Miyagishi H, Saito A, Imai T, Takeda K, Ishii D, Takeda H. Neuroprotective effect of yokukansan against cytotoxicity induced by corticosterone on mouse hippocampal neurons. Phytomedicine 21, 1458-1465, 2014. (Original article)
39. Kato H, Tsuji M, Miyagawa K, Takeda K, Takeda H. Repeated exposure to stress stimuli during ethanol consumption prolongs withdrawal-induced emotional abnormality in mice. Eur J Pharmacol 721, 29-34, 2013. (Original article)
40. Arai I, Tsuji M, Takeda H, Akiyama N, Saito S. A single dose of interleukin-31 (IL-31) causes continuous itch-associated scratching behaviour in mice. Exp Dermatol 22, 669-671, 2013. (Original article)
41. Tsuji M, Takeuchi T, Miyagawa K, Takeda H. Role of brain 5-HT7 receptors as a functional molecule involved in the development of stress adaptation. Nihon Shinkei Seishin Yakurigaku Zasshi 32, 187-93, 2012. (Review, Japanese)
42. Miyagawa K, Tsuji M, Takeda H. Possible involvement of histone acetylation in the development of emotional resistance to stress stimuli in mice. Behav Brain Res 235, 318-25, 2012. (Original article)
43. Nakatani Y, Amano T, Tsuji M, Takeda H. Corticosterone suppresses the proliferation of BV2 microglia cells via glucocorticoid, but not mineralocorticoid receptor. Life Sci 91, 761-770, 2012. (Original article)
44. Miyagawa K, Tsuji M, Fujimori K, Saito Y, Takeda H. Prenatal stress induces anxiety-like behavior together with the disruption of central serotonin neurons in mice. Neurosci Res 70, 111-117, 2012. (Original article)