【学位・学歴】
東北薬科大学薬学部卒業 学士 (薬学)
東北医科薬科大学大学院薬学研究科修了 博士（薬科学）

【職歴】
三菱化学メディエンス株式会社創薬支援事業部安全性研究部研究員、昭和大学医学部研究生、調剤薬局薬剤師を経て現職。

【資格】
薬剤師免許

中枢神経精神薬理
脳腸相関

・ストレス性精神疾患の病態解明と新規治療戦略の開発
・脳腸相関と精神疾患の関連性

【researchmap】
https://researchmap.jp/taka8922

【論文】

1. Kohei Takahashi, Minoru Tsuji, Osamu Nakagawasai, Soh Katsuyama, Kazuya Miyagawa, Kazuhiro Kurokawa, Atsumi Mochida-Saito, Hiroshi Takeda, Takeshi Tadano. Polarization to M1-type microglia in the hippocampus is involved in depression-like behavior in a mouse model of olfactory dysfunction. Neurochemistry international 105723-105723 2024年3月13日.
2. Kohei Takahashi, Kazuhiro Kurokawa, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuji. Repeated antibiotic drug treatment negatively affects memory function and glutamatergic nervous system of the hippocampus in mice. Neuroscience letters 137711-137711 2024年3月1日.
3. Kohei Takahashi, Kazuhiro Kurokawa, Lihua Hong, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuji. Hippocampal and gut AMPK activation attenuates enterocolitis-like symptoms and co-occurring depressive-like behavior in ulcerative colitis model mice: Involvement of brain-gut autophagy. Experimental neurology 373 114671-114671 2024年3月.
4. Kohei Takahashi, Lihua Hong, Kazuhiro Kurokawa, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuji. Brexpiprazole prevents colitis-induced depressive-like behavior through myelination in the prefrontal cortex. Progress in neuro-psychopharmacology & biological psychiatry 121 110666-110666 2023年3月8日.
5. Kohei Takahashi, Minoru Tsuji, Osamu Nakagawasai, Soh Katsuyama, Lihua Hong, Kazuya Miyagawa, Kazuhiro Kurokawa, Atsumi Mochida-Saito, Hiroshi Takeda, Takeshi Tadano. Donepezil prevents olfactory dysfunction and α-synuclein aggregation in the olfactory bulb by enhancing autophagy in zinc sulfate-treated mice Behavioural brain research 438 114175-114175 2023年2月13日.
6. Kohei Takahashi, Kazuhiro Kurokawa, Lihua Hong, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuji. Correlation between the reduction in hippocampal SirT2 expression and depressive-like behaviors and neurological abnormalities in olfactory bulbectomized mice. Neuroscience research 182 76-80 2022年9月.
7. Kohei Takahashi, Kazuhiro Kurokawa, Lihua Hong, Kazuya Miyagawa, Atsumi Mochida-Saito, Masahiro Iwasa, Hiroyuki Iwasa, Osamu Nakagawasai, Takeshi Tadano, Hiroshi Takeda, Minoru Tsuji. Antidepressant effects of Enterococcus faecalis 2001 through the regulation of prefrontal cortical myelination via the enhancement of CREB/BDNF and NF-κB p65/LIF/STAT3 pathways in olfactory bulbectomized mice Journal of Psychiatric Research 148 137-148 2022年4月.
8. Kohei Takahashi, Kazuhiro Kurokawa, Lihua Hong, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuji. Disturbance of prefrontal cortical myelination in olfactory bulbectomized mice is associated with depressive-like behavior. Neurochemistry international 148 105112-105112 2021年9月.
9. Kohei Takahashi, Osamu Nakagawasai, Masashi Uwabu, Masahiro Iwasa, Hiroyuki Iwasa, Minoru Tsuji, Hiroshi Takeda, Takeshi Tadano. Immunological benefits of Enterococcus faecalis 2001 in healthy volunteers Jpn Pharmacol Ther 49(6) 913-916 2021年6月29日.
10. Kohei Takahashi, Minoru Tsuji, Osamu Nakagawasai, Soh Katsuyama, Kazuya Miyagawa, Kazuhiro Kurokawa, Atsumi Mochida-Saito, Masahiro Iwasa, Hiroyuki Iwasa, Hiroshi Takeda, Takeshi Tadano. Activation of cholinergic system partially rescues olfactory dysfunction-induced learning and memory deficit in mice. Behavioural brain research 408 113283-113283 2021年6月25日.
11. Kohei Takahashi, Osamu Nakagawasai, Takeharu Nakajima, Myu Okubo, Yuki Nishimura, Wakana Sakuma, Ryota Yamagata, Wataru Nemoto, Kazuya Miyagawa, Kazuhiro Kurokawa, Atsumi Mochida-Saito, Minoru Tsuji, Hiroshi Takeda, Takeshi Tadano, Koichi Tan-No. Dopamine D2 receptor supersensitivity in the hypothalamus of olfactory bulbectomized mice. Brain research 1746 147015-147015 2020年11月1日.
12. Kohei Takahashi, Kazuhiro Kurokawa, Kazuya Miyagawa, Atsumi Mochida-Saito, Yukio Nemoto, Hiroyuki Iwasa, Osamu Nakagawasai, Takeshi Tadano, Hiroshi Takeda, Minoru Tsuji. Antidementia effects of Enterococcus faecalis 2001 are associated with enhancement of hippocampal neurogenesis via the ERK-CREB-BDNF pathway in olfactory bulbectomized mice. Physiology & behavior 223 112997-112997 2020年9月1日.
13. Kohei Takahashi, Osamu Nakagawasai, Wataru Nemoto, Takayo Odaira, Wakana Sakuma, Hiroshi Onogi, Hiroaki Nishijima, Ryuji Furihata, Yukio Nemoto, Hiroyuki Iwasa, Koichi Tan-No, Takeshi Tadano. Effect of Enterococcus faecalis 2001 on colitis and depressive-like behavior in dextran sulfate sodium-treated mice: involvement of the brain-gut axis. Journal of neuroinflammation 16(1) 201-201 2019年10月31日.
14. Kohei Takahashi, Osamu Nakagawasai, Wakana Sakuma, Wataru Nemoto, Takayo Odaira, Jia-Rong Lin, Hiroshi Onogi, Lalit K Srivastava, Koichi Tan-No. Prenatal treatment with methylazoxymethanol acetate as a neurodevelopmental disruption model of schizophrenia in mice. Neuropharmacology 150 1-14 2019年5月15日.
15. Kohei Takahashi, Osamu Nakagawasai, Wataru Nemoto, Shogo Kadota, Jinichi Isono, Takayo Odaira, Wakana Sakuma, Yuichiro Arai, Takeshi Tadano, Koichi Tan-No. Memantine ameliorates depressive-like behaviors by regulating hippocampal cell proliferation and neuroprotection in olfactory bulbectomized mice. Neuropharmacology 137 141-155 2018年7月15日.
16. Kohei Takahashi, Osamu Nakagawasai, Wataru Nemoto, Takayo Odaira, Wakana Sakuma, Koichi Tan-No. Antidepressant-like effect of aripiprazole via 5-HT1A, D1, and D2 receptors in the prefrontal cortex of olfactory bulbectomized mice. Journal of pharmacological sciences 137(3) 241-247 2018年7月.
17. Kohei Takahashi, Osamu Nakagawasai, Masae Sugawara, Atsushi Sato, Wataru Nemoto, Takeshi Tadano, Koichi Tan-No. Kappa Opioid Receptor Agonist Administration in Olfactory Bulbectomized Mice Restores Cognitive Impairment through Cholinergic Neuron Activation. Biological & pharmaceutical bulletin 41(6) 957-960 2018年.
18. Kohei Takahashi, Osamu Nakagawasai, Wataru Nemoto, Takayo Odaira, Yuichiro Arai, Tadashi Hisamitsu, Koichi Tan-No. Time-dependent role of prefrontal cortex and hippocampus on cognitive improvement by aripiprazole in olfactory bulbectomized mice EUROPEAN NEUROPSYCHOPHARMACOLOGY 27(10) 1000-1010 2017年10月.
19. Kohei Takahashi, Osamu Nakagawasai, Wataru Nemoto, Takeharu Nakajima, Yuichiro Arai, Tadashi Hisamitsu, Koichi Tan-No. Alterations in behavioral responses to dopamine agonists in olfactory bulbectomized mice: relationship to changes in the striatal dopaminergic system. Psychopharmacology 233(7) 1311-22 2016年4月.

【学会賞】

• 日本ストレス学会　日本ストレス学会奨励賞（高田賞） 2021年
  研究題目：潰瘍性大腸炎誘発性うつ様行動における前頭前皮質セロトニン神経変性並びにミエリン形成障害の関与
• 第22回活性アミンに関するワークショップ　若手研究者奨励賞　2018年
  研究題目：メマンチンの海馬ドパミン神経系を介した抗うつ効果

【外部資金獲得】

1. 科学研究費補助金 (若手研究) ：潰瘍性大腸炎によるうつ発症メカニズムの解明：脳腸ＡＭＰＫの関与と新規治療法の開発 (2021年度～2023年度)
2. 公益財団法人 武田科学振興財団　研究助成金：ミエリン形成障害仮説に基づくうつ症状発症メカニズムの解明 (2020年度～2023年度)
3. 科学研究費補助金 (研究活動スタート支援) ：脳腸相関の概念を基軸とした潰瘍性大腸炎によるうつ症状の発症メカニズムの解明 (2019年度～2020年度)