【学歴】
名古屋市立大学 薬学部
名古屋市立大学大学院 薬学研究科 博士前期課程 修士(薬学)
名古屋市立大学大学院 薬学研究科 博士後期課程 博士(薬学)

【職歴】
福島県立医科大学 医学部 助手
福島県立医科大学 医学部 助教
福島県立医科大学 医学部 講師
University of California San Francisco, Visiting Assistant Professor
静岡県立大学 薬学部 講師
静岡県立大学 薬学部 准教授
国際医療福祉大学 薬学部 教授

【資格】
薬剤師
スポーツファーマシスト
薬理学エデュケーター
日本性差医学・医療学会指導士

生理学、薬理学、毒性学

ミトコンドリアに着目したサルコペニア新規治療戦略の構築

【researchmap】
https://researchmap.jp/kazuho

【著書】

• ウィメンズヘルスケアのための薬の使い方
• コメディカルのための薬理学　第4版

【主な論文】

• Iseki Y, Ono Y, Hibi C, Tanaka S, Takeshita S, Maejima Y, Kurokawa J, Murakawa M, Shimomura K, Sakamoto K*. 2021. Opening of Intermediate Conductance Ca2+-Activated K+ Channels in C2C12 Skeletal Muscle Cells Increases the Myotube Diameter via the Akt/Mammalian Target of Rapamycin Pathway. J Pharmacol Exp Ther 376:454–462.
• Aghasafari P, Yang P-C, Kernik DC, Sakamoto K, Kanda Y, Kurokawa J, Vorobyov I, Clancy CE*. 2021. A deep learning algorithm to translate and classify cardiac electrophysiology. eLife 10:68335
• Ono Y*, Maejima Y, Saito M, Sakamoto K, Horita S, Shimomura K, Inoue S, Kotani J. 2020. TAK-242, a specific inhibitor of Toll-like receptor 4 signalling, prevents endotoxemia-induced skeletal muscle wasting in mice. Sci Rep 10:694.
• Sakamoto K, Sakatoku K, Sugimoto S, Iwasaki N, Sano Y, Yamaguchi M, Kurokawa J*. 2019. Continued exposure of anti-cancer drugs to human iPS cell-derived cardiomyocytes can unmask their cardiotoxic effects. J Pharmacol Sci 140:345–349
• Dannhauser PN, Camus SM, Sakamoto K, Sadacca LA, Torres JA, Camus MD, Briant K, Vassilopoulos S, Rothnie A, Smith CJ, Brodsky FM*. 2017. CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function. J Biol Chem 292:20834–20844.
• Tohyama S, Fujita J*, Fujita C, Yamaguchi M, Kanaami S, Ohno R, Sakamoto K, Kodama M, Kurokawa J, Kanazawa H, Seki T, Kishino Y, Okada M, Nakajima K, Tanosaki S, Someya S, Hirano A, Kawaguchi S, Kobayashi E, Fukuda K. 2017. Efficient Large-Scale 2D Culture System for Human Induced Pluripotent Stem Cells and Differentiated Cardiomyocytes. Stem cell reports. 9:1406-1414.
• Ono Y, Sakamoto K*. 2017. Lipopolysaccharide inhibits myogenic differentiation of C2C12 myoblasts through the Toll-like receptor 4-nuclear factor-κB signaling pathway and myoblast-derived tumor necrosis factor-α. PLoS One 12:e0182040.
• Tanaka S, Ono Y, Sakamoto K*. 2017. DCEBIO facilitates myogenic differentiation via intermediate conductance Ca2+ activated K+ channel activation in C2C12 myoblasts. J Pharmacol Sci 133:276–279.
• Sakamoto K, Suzuki Y, Yamamura H, Ohya S, Muraki K, Imaizumi Y*. 2017. Molecular mechanisms underlying pimaric acid-induced modulation of voltage-gated K+ channels. J Pharmacol Sci 133:223–231.
• Hoshino S, Sakamoto K, Vassilopoulos S, Camus S, Griffin CA, Esk C, Torres JA, Ohkoshi N, Ishii A, Tamaoka A, Funke BH, Kucherlapati R, Margeta M, Rando TA, Brodsky FM*. 2013. The CHC22 Clathrin-GLUT4 Transport Pathway Contributes to Skeletal Muscle Regeneration. PLoS One 8:e77787.
• Takahashi K*, Sakamoto K, Kimura J. 2012. Hypoxic Stress Induces Transient Receptor Potential Melastatin 2 (TRPM2) Channel Expression in Adult Rat Cardiac Fibroblasts. J Pharmacol Sci 118:186–197.
• Sakamoto K*, Wada I, Kimura J. 2011. Inhibition of Rab1 GTPase and endoplasmic reticulum-to-Golgi trafficking underlies statin’s toxicity in rat skeletal myofibers. J Pharmacol Exp Ther 338:62–69.
• Tanaka S, Sakamoto K*, Yamamoto M, Mizuno A, Ono T, Waguri S, Kimura J. 2010. Mechanism of statin-induced contractile dysfunction in rat cultured skeletal myofibers. J Pharmacol Sci 114:454–463.
• Sakamoto K*, Owada Y, Shikama Y, Wada I, Waguri S, Iwamoto T, Kimura J. 2009. Involvement of Na+/Ca2+ exchanger in migration and contraction of rat cultured tendon fibroblasts. J Physiol 587:5345–5359.
• Sakamoto K, Ohya S, Muraki K, Imaizumi Y*. 2008. A novel opener of large-conductance Ca2+ -activated K+ (BK) channel reduces ischemic injury in rat cardiac myocytes by activating mitochondrial K(Ca) channel. J Pharmacol Sci 108:135–139.
• Sakamoto K*, Mikami H, Kimura J. 2008. Involvement of organic anion transporting polypeptides in the toxicity of hydrophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres. Br J Pharmacol 154:1482–1490.
• Sakamoto K*, Honda T, Yokoya S, Waguri S, Kimura J. 2007. Rab-small GTPases are involved in fluvastatin and pravastatin-induced vacuolation in rat skeletal myofibers. FASEB J 21:4087–4094.
• Sakamoto K, Nonomura T, Ohya S, Muraki K, Ohwada T, Imaizumi Y*. 2006. Molecular mechanisms for large conductance Ca2+-activated K+ channel activation by a novel opener, 12,14-dichlorodehydroabietic acid. J Pharmacol Exp Ther 316:144–153.
• Ohya S, Kuwata Y, Sakamoto K, Muraki K, Imaizumi Y*. 2005. Cardioprotective effects of estradiol include the activation of large-conductance Ca2+-activated K+ channels in cardiac mitochondria. Am J Physiol Heart Circ Physiol 289:H1635–H1642.
• Imaizumi Y*, Sakamoto K, Yamada A, Hotta A, Ohya S, Muraki K, Uchiyama M, Ohwada T. 2002. Molecular basis of pimarane compounds as novel activators of large-conductance Ca2+-activated K+ channel alpha-subunit. Mol Pharmacol 62:836–846.
　他多数



【主な受賞歴】

• 日本薬理学会JPS優秀査読者賞
• 日本薬学会薬理系部会 奨励賞
• 福島医学会 学術奨励賞
　他多数