【学歴】
北海道大学薬学部卒業
北海道大学大学院薬学研究科修士課程修了　修士（薬学）
大阪大学大学院医学系研究科博士課程修了　博士（医学）

【職歴】
近畿大学医学部　助手／助教
Max-Planck Institute of Immunobiology and Epigenetics　博士研究員
滋賀医科大学医学部　准教授
姫路獨協大学薬学部　教授

実験病理学、免疫発生学、細胞動態学／がん薬物療法学

・外分泌腺の組織形成機構および病態形成機構の解明
・外分泌腺のがん化機構の解明

【researchmap】
https://researchmap.jp/dskngkb

【主な原著論文】

1. Kaibori Y, Tamoto S, Okuda S, Matsuo K, Nakayama T, Nagakubo D*. CCL28: A Promising Biomarker for Assessing Salivary Gland Functionality and Maintaining Healthy Oral Environments. Biology (Basel), 13:147, 2024. (* Corresponding author)
2. Kaibori Y, Yamashita K, Nagakubo D*. The altered production and property of saliva induced by ingesting fermented food ingredients affect the oral microbiome composition in mice. Biosci. Biotechnol. Biochem., 87:228–235, 2023. (* Corresponding author)
3. Kaibori Y, Nagakubo D*. CCR3 blockage elicits polyploidization associated with the signatures of epithelial-mesenchymal transition in carcinoma cell lines. Cancer Gene Ther., 30:137–148, 2023. (* Corresponding author)
4. Nagakubo D, Hirakawa M, Iwanami N, Boehm T. Limits to in vivo fate changes of epithelia in thymus and parathyroid by ectopic expression of transcription factors Gcm2 and Foxn1. Sci. Rep., 12(1):13554, 2022.
5. Swann JB, Nusser A, Morimoto R, Nagakubo D, Boehm T. Retracing the evolutionary emergence of thymopoiesis. Sci. Adv., 6(48):eabd9585, 2020.
6. Matsui M#, Nagakubo D#, Satooka H, Hirata T. A novel Siglec-F+ neutrophil subset in the mouse nasal mucosa exhibits an activated phenotype and is increased in an allergic rhinitis model. Biochem. Biophys. Res. Commun., 526:599–606, 2020. (# Equal contribution)
7. Hirakawa M, Nagakubo D, Kanzler B, Avilov S, Krauth B, Happe C, Swann JB, Nusser A, Boehm T. Fundamental parameters of the developing thymic epithelium in the mouse. Sci. Rep., 8(1):11095, 2018.
8. Matsuo K, Nagakubo D, Komori Y, Fujisato S, Takeda N, Kitamatsu M, Nishiwaki K, Quan YS, Kamiyama F, Oiso N, Kawada A, Yoshie O, Nakayama T. CCR4 is critically involved in skin allergic inflammation of BALB/c mice. J. Invest. Dermatol., 138:1764–1773, 2018.
9. Matsuo K, Nagakubo D, Yamamoto S, Shigeta A, Tomida S, Fujita M, Hirata T, Tsunoda I, Nakayama T, Yoshie O. CCL28-deficient mice have reduced IgA antibody-secreting cells and an altered microbiota in the colon. J. Immunol., 200:800–809, 2018.
10. Nagakubo D, Swann J, Birmelin S, Boehm T. Autoimmunity associated with chemically induced thymic dysplasia. Int. Immunol., 29:385–390, 2017.
11. Satooka H, Nagakubo D, Sato T, Hirata T. The ERM protein moesin regulates CD8+ regulatory T cell homeostasis and self-tolerance. J. Immunol., 199:3418–3426, 2017.
12. Nagakubo D, Krauth B, Boehm T. Genetic and non-genetic determinants of thymic epithelial cell number and function. Sci. Rep., 7(1):10314, 2017.
13. Nagakubo D, Yoshie O, Hirata T. Upregulated CCL28 expression in the nasal mucosa in experimental allergic rhinitis: Implication for CD4+ memory T cell recruitment. Cell. Immunol., 302:58–62, 2016.
14. Swann JB, Weyn A, Nagakubo D, Bleul CC, Toyoda A, Happe C, Netuschil N, Hess I, Haas-Assenbaum A, Taniguchi Y, Schorpp M, Boehm T. Conversion of the thymus into a bipotent lymphoid organ by replacement of FOXN1 with its paralog, FOXN4. Cell Reports, 8:1184–1197, 2014.

【総説】

1. Nagakubo D*, Kaibori Y. Oral Microbiota: The Influences and Interactions of Saliva, IgA, and Dietary Factors in Health and Disease. Microorganisms, 11:2307, 2023. (* Corresponding author)

【解説】

1. 長久保　大輔. アレルギー性鼻炎におけるCD4+ T細胞の動態制御機構. アレルギーの臨床, 37:1270–1272, 2017.（東京, 北隆館）
2. 長久保　大輔, 村井 稔幸, 田中 稔之, 宮坂 昌之. HEV産生蛋白質mac25/angiomodulinはケモカインを捕捉し、提示する. 臨床免疫, 41:578–582, 2004.（東京, 科学評論社）